RNA Synthesis
For a considerably long period in the history of biology, RNA (ribonucleic acid) was once regarded merely as a bridge between DNA and protein molecules. In recent years, with the deep understanding of important roles of RNA in the regulation of gene expression, protein synthesis, and the occurrence and development of diseases, its vital biological functions as a key molecule in cells have increasingly gained attention. However, to date, RNA is mainly produced through chemical synthesis or in vitro transcription methods and is limited by complex supply chains with high production costs, greatly restricting its wide application.
Biocreatech has innovated synthetic biology-based technology for RNA production. By designing and constructing cell factories which can produce RNA efficiently, we have achieved highly efficient cellular synthesis of RNA that is strikingly different from traditional methods.
RNA interference (RNAi) technology can selectively inhibit expression of key genes in pests and pathogens to kill them, thereby achieving disease control. RNA biopesticides have the following significant advantages:
1. High selectivity: They can target the genes of specific pests or pathogens, lowering ecological risks;
2. Environmental friendliness: RNA molecules are easily degradable, do not accumulate in the environment, and reduce pollution and toxicity issues;
3. Low toxicity and safety: RNA is non-toxic to humans and non-target animals, less likely to induce drug resistance.
We believe that RNA biopesticides will become an important prevention and control tool for green agriculture, and our innovative technology of RNA cellular synthesis will underpin the early realization of this vision.
The applications of RNA drugs in medicine fields such as vaccines, cancer, and gene therapy are growing. RNA drugs, including mRNA (e.g., mRNA vaccines for COVID-19), small RNA drugs (such as siRNA, miRNA, and antisense RNA), and RNA aptamers, are growing rapidly in the healthcare sector. RNA drugs offer advantages like flexible design and short development cycles, promising treatment of tumors, rare diseases, and infectious diseases. They are gradually becoming the third major drug class following small molecules and antibodies.
Biocreatech leverages its technological advancement in synthetic biology, deploying a highly efficient cell-based method to produce RNA drugs at low-cost. We focus on the precision medicine field with broad applications and have R&D pipelines on RNA orphan drugs for rare diseases.
The extracellular matrix (ECM) plays a central role in maintaining the structure and function of the skin. It provides mechanical support, regulates cell migration, proliferation and differentiation, and preserves skin elasticity and barrier function. The decline in ECM function is closely associated with skin aging, which not only impairs tissue repair capacity but also accelerates photoaging and loss of skin elasticity. With aging, collagen and elastic fibers in the ECM gradually degrade, leading to reduced skin elasticity and wrinkle formation. Restoring and maintaining ECM integrity has become an important strategy for anti-aging and skin regeneration.
Biocreatech's pioneering RNA aesthetic medicine products can in situ regenerate ECM proteins in the epidermis, dermis and hypodermis of skins，and consequently provide structurally and functionally intact key components such as collagen and elastin, that promptly repair the skin's fibrous network structure, endowing kins with moisture, elasticity and youthful vitality.
